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In animal models, NOD2 and Atg16l1 mutant mice exhibit specific immune cell composition and cytokine profile changes in a natural microbiome environment, directly demonstrating that both genetics and the environment jointly regulate gut immunity [245]

Drink plenty of water and eat a diet rich in sulfur-containing vegetables (like broccoli, kale, and garlic), which provide the natural building blocks for your body's antioxidant production

Most liposomal glutathione and vitamin C supplements are formulated to be vegetarian-friendly, though this depends on the specific capsule shell and source used by each brand

Synthesis methods The analysis was done using Review Manager Software (RevMan 5.4.1, The Nordic Cochrane Centre, The Cochrane Collaboration, Denmark) under the inverse variance method

Song et al., 2025b)